Structure of PDB 5guv Chain A

Receptor sequence
>5guvA (length=818) Species: 10090 (Mus musculus) [Search protein sequence]
RISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLARV
TALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYIH
SKVKVIYKAPSENWAMEGTYFFQLWYNQEYARFESPPKTQPTEDNKHKFC
LSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGDSVYLPP
EAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYLDAPEPYRIGRIKEIHC
GKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTDINMLYWSDEEAVVN
FSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEAYNSKTKNFEDPPNH
ARSPIKLPKLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRL
NNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGF
SGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSYRDSMV
LKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPE
PLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEIQN
GASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKDMSPLVAARMRHIP
LFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGYSSTGALRGVCSCA
EGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNP
EPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYRFFGNILDRHRQVGNAV
PPPLAKAIGLEIKLCLLS
3D structure
PDB5guv Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.
ChainA
Resolution3.078 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1) C447 E487 R531 R533
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1479 C1481 H1504 C697 C699 H722
BS02 ZN A H796 C823 C897 C900 H64 C91 C150 C153
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5guv, PDBe:5guv, PDBj:5guv
PDBsum5guv
PubMed29381856
UniProtP13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

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