Structure of PDB 5gut Chain A

Receptor sequence
>5gutA (length=794) Species: 10090 (Mus musculus) [Search protein sequence]
MKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLARVTALWEDKN
GQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYIHSKVKVIYK
APSENWAMEGYFFQLWYNQEYARFESPPKTQPHKFCLSCIRLAELRQKEM
PKVLEQIEEVDGRVYCSSITKNGVVYRLGDSVYLPPEAFTFNIKVASPDP
VNETLYPEHYRKYDAPEPYRIGRIKEIHCGKKKGKVNEADIKLRLYKFYR
PENTHRSYNGSYHTDINMLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQ
DYSQGGPDRFYFLEAYNSKTKNFEDPPNHARSPLPKLRTLDVFSGCGGLS
EGFHQAGISETLWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGE
VTNSLGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKASLVVSFL
SYCDYYRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAG
QYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVS
NITRLSSGPFRTITVRDTMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRG
SHYQPILRDHICKDMSPLVAARMRHIPLFPGSDWRDLPNIQVRLGDGVIA
HKLQYTFHDVKNGYSSTGALRGVCSCAEGKACDPESRQFSTLIPWCLPHT
GNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVREC
ARSQGFPDSYRFFGNILDRHRQVGNAVPPPLAKAIGLEIKLCLL
3D structure
PDB5gut Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.
ChainA
Resolution2.099 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1) C424 E464 R508 R510
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A F1148 S1149 G1153 L1154 E1171 M1172 D1193 C1194 L1250 N1580 A1581 V1582 F343 S344 G348 L349 E366 M367 D388 C389 L445 N775 A776 V777 PDBbind-CN: -logKd/Ki=6.29,Kd=0.51uM
BS02 ZN A H796 C823 C897 C900 H56 C83 C136 C139
BS03 ZN A C1479 C1481 C1487 H1504 C674 C676 C682 H699
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5gut, PDBe:5gut, PDBj:5gut
PDBsum5gut
PubMed29381856
UniProtP13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

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