Structure of PDB 5gtr Chain A

Receptor sequence

>5gtrA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSESEASMMGLLTNLADRELVHMINWA
KRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLD
RNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTF
LSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLIL
SHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAH

3D structure

PDB

5gtr Structural Basis of Inhibition of ER alpha-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides

Chain

Resolution

2.804 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	V355 I358 K362 L372 V376 E542 M543	V44 I47 K51 L61 V65 E231 M232
BS02	EST	A	L346 A350 E353 L387 L391 R394 M421 I424 H524 L525	L35 A39 E42 L76 L80 R83 M110 I113 H213 L214	BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM

External links

PDB	RCSB:5gtr, PDBe:5gtr, PDBj:5gtr
PDBsum	5gtr
PubMed	29045135
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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