Structure of PDB 5gto Chain A

Receptor sequence
>5gtoA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKHITPLKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLD
LNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQ
DNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE
TDMSLHPLLQEIYKDLY
3D structure
PDB5gto Structural basis for differential activities of enantiomeric PPAR gamma agonists: Binding of S35 to the alternate site.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K301 L311 Q314 V315 L318 K319 L468 E471 D475 K91 L101 Q104 V105 L108 K109 L258 E261 D265
BS02 T35 A E259 I262 F264 I267 T268 P269 L270 R280 Q283 G284 F287 I341 E53 I56 F58 I61 T62 P63 L64 R70 Q73 G74 F77 I131 BindingDB: EC50=183nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:5gto, PDBe:5gto, PDBj:5gto
PDBsum5gto
PubMed28342850
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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