Structure of PDB 5gso Chain A

Receptor sequence
>5gsoA (length=181) Species: 39054 (Enterovirus A71) [Search protein sequence]
GPSLDFALSLLRRNVRQVQTDQGHFTMLGVRDRLAVLPRHSQPGKTIWIE
HKLVNVLDAVELVDEQGVNLELTLITLDTNEKFRDITKFIPENISTASDA
TLVINTEHMPSMFVPVGDVVQYGFLNLSGKPTHRTMMYNFPTKAGQCGGV
VTSVGKIIGIHIGGNGRQGFCAGLKRSYFAS
3D structure
PDB5gso Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V30 H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) V30 H40 E71 G145 C147
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GI A H40 E71 K130 T142 K143 C147 H161 I162 G163 G164 H40 E71 K130 T142 K143 C147 H161 I162 G163 G164 PDBbind-CN: -logKd/Ki=6.96,IC50=0.11uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0018144 RNA-protein covalent cross-linking
GO:0019062 virion attachment to host cell
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0039618 T=pseudo3 icosahedral viral capsid

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Cellular Component
External links
PDB RCSB:5gso, PDBe:5gso, PDBj:5gso
PDBsum5gso
PubMed28461310
UniProtE7E815

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