Structure of PDB 5gp1 Chain A

Receptor sequence
>5gp1A (length=262) Species: 64320 (Zika virus) [Search protein sequence]
TGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGH
AVSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGY
TKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSS
PEVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYG
GGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKY
EEDVNLGSGTRA
3D structure
PDB5gp1 Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design
ChainA
Resolution2.444 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTA A K13 L16 N17 M19 F24 K28 S151 S152 S215 K10 L13 N14 M16 F21 K25 S148 S149 S212
BS02 SAH A S56 G58 G81 C82 G86 W87 T104 H110 V132 F133 D146 I147 S53 G55 G78 C79 G83 W84 T101 H107 V129 F130 D143 I144
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5gp1, PDBe:5gp1, PDBj:5gp1
PDBsum5gp1
PubMed27866982
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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