Structure of PDB 5goy Chain A

Receptor sequence
>5goyA (length=598) Species: 9606 (Homo sapiens) [Search protein sequence]
ATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYV
NNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEE
GLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLK
RGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLI
NAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWT
PNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGY
LSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNY
TLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIR
PEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLT
PDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPW
KRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPP
PACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAK
3D structure
PDB5goy The crystal structure of human cytosolic methionyl-tRNA synthetase in complex with methionine
ChainA
Resolution2.278 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H280 N283 C389 C392 C435 C438 K593 K596
Catalytic site (residue number reindexed from 1) H55 N58 C164 C167 C210 C213 K368 K371
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C389 C392 C435 C438 C164 C167 C210 C213
BS02 ZN A C405 C408 C418 C421 C180 C183 C193 C196
BS03 MET A L272 D312 W518 A521 N556 L47 D87 W293 A296 N331
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5goy, PDBe:5goy, PDBj:5goy
PDBsum5goy
PubMed
UniProtP56192|SYMC_HUMAN Methionine--tRNA ligase, cytoplasmic (Gene Name=MARS1)

[Back to BioLiP]