Structure of PDB 5gof Chain A

Receptor sequence
>5gofA (length=390) Species: 9606 (Homo sapiens) [Search protein sequence]
PVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDD
LVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPS
GIGHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHAGCLVR
VFWPKAKCALLRDDLVLVDSPGTDELDSWIDKFCLDADVFVLVANSESTL
MNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLH
FLVEELKVVNALEAQNRIFFVSAKEVLSARKQKVALAEGFHARLQEFQNF
EQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSA
RLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLPS
3D structure
PDB5gof MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion
ChainA
Resolution1.604 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A T84 S85 G87 K88 S89 S90 N237 R238 D240 S284 K286 T81 S82 G84 K85 S86 S87 N225 R226 D228 S272 K274 MOAD: Kd=90.1uM
PDBbind-CN: -logKd/Ki=4.05,Kd=90.1uM
BS02 ZN A C111 H144 H147 C156 C108 H141 H144 C147
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0008053 mitochondrial fusion
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5gof, PDBe:5gof, PDBj:5gof
PDBsum5gof
PubMed28114303
UniProtQ8IWA4|MFN1_HUMAN Mitofusin-1 (Gene Name=MFN1)

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