Structure of PDB 5gme Chain A

Receptor sequence
>5gmeA (length=324) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence]
LKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTL
NDKNIVIVNDRILSEDEMKEYAGRVLDTFKKIVGKEFHVKVESKSKFPIN
AGLASSAAGIAALAFSLNELLELNLKSEELSKIARLGSGSACRSMFGGFV
VWNKGEREDGEDSYCYQIFRHDYWSELVDIIPILSEKEKKISSRKGMIRS
AETSELMECRLKYIEKTFNEVIEAIRNRDEKKFYYLMMRHSNSMHAVILD
SWPSFFYLNDTSIRIMEWIHDYGKAGYTFDAGPNPHIFTTERNIGDILEF
LKSLEIKRIIVSKVGDGPKVLSRE
3D structure
PDB5gme A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate Decarboxylase into a Kinase
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.33: diphosphomevalonate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DP6 A A14 Y18 W19 K21 N28 S139 G140 S141 R144 S194 R195 M198 D281 A13 Y17 W18 K20 N27 S138 G139 S140 R143 S193 R194 M197 D280
BS02 ADP A L64 E68 Y72 S94 S106 S107 G110 L63 E67 Y71 S93 S105 S106 G109
BS03 AMP A R22 G23 K155 E157 E159 R21 G22 K154 E156 E158
Gene Ontology
Molecular Function
GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5gme, PDBe:5gme, PDBj:5gme
PDBsum5gme
PubMed28003359
UniProtQ97UL5|DMD_SACS2 Diphosphomevalonate decarboxylase (Gene Name=SSO2989)

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