Structure of PDB 5gjc Chain A

Receptor sequence
>5gjcA (length=429) Species: 64320 (Zika virus) [Search protein sequence]
SMLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKTRLRTVILAPTRVVAAE
MEEALRGLPVRYMTTGTEIVDLMCHATFTSRLLQPIRVPNYNLYIMDEAH
FTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFPDSNSPIMDTEV
EVPERAWSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLTKAGKRVIQLSR
KTFETEFQKTKHQEWDFVVTTDISEMGANFKADRVIDSRRCLKPVILDGE
RVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYLYGGGCAETDEDHAHWL
EARMLLDNIYLQDGLIASLYRPEADKVAAIEGEFKLRTEQRKTFVELMKR
GDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSVPAEVWTRHGEKR
VLKPRWMDARVCSDHAALKSFKEFAAGKR
3D structure
PDB5gjc Structural basis of Zika virus helicase in recognizing its substrates
ChainA
Resolution2.204 Å
3D
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A T201 E286 T20 E98
BS02 ATP A G197 G199 K200 T201 R202 E286 R462 G16 G18 K19 T20 R21 E98 R274
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5gjc, PDBe:5gjc, PDBj:5gjc
PDBsum5gjc
PubMed27430951
UniProtA0A0U4DG08

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