Structure of PDB 5gj9 Chain A

Receptor sequence
>5gj9A (length=298) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
KFPVVDLSKLNGEERDQTMALINEACENWGFFEIVNHGLPHDLMDKIEKM
TKDHYKTCQEQKFNDMLKSKGLDNLETEVEDVDWESTFYVRHLPQSNLND
ISDVSDEYRTAMKDFGKRLENLAEDLLDLLCENLGLEKGYLKKVFHGTKG
PTFGTKVSNYPPCPKPEMIKGLRAHTDAGGIILLFQDDKVSGLQLLKDGD
WIDVPPLNHSIVINLGDQLEVITNGKYKSVLHRVVTQQEGNRMSVASFYN
PGSDAEISPATSLVEKDSEYPSFVFDDYMKLYAGVKFQPKEPRFAAMK
3D structure
PDB5gj9 Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K161 H180 D182 H237
Catalytic site (residue number reindexed from 1) K156 H175 D177 H232
Enzyme Commision number 1.14.17.4: aminocyclopropanecarboxylate oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H180 D182 H237 H175 D177 H232
BS02 VGL A K161 L177 H180 D182 L189 H237 A251 K156 L172 H175 D177 L184 H232 A246 PDBbind-CN: -logKd/Ki=4.99,Kd=10.2uM
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0009815 1-aminocyclopropane-1-carboxylate oxidase activity
GO:0016491 oxidoreductase activity
GO:0031418 L-ascorbic acid binding
GO:0046872 metal ion binding
Biological Process
GO:0006952 defense response
GO:0009693 ethylene biosynthetic process
GO:0009727 detection of ethylene stimulus
GO:0010030 positive regulation of seed germination
GO:0071398 cellular response to fatty acid
GO:0071732 cellular response to nitric oxide
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009505 plant-type cell wall
GO:0009506 plasmodesma

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5gj9, PDBe:5gj9, PDBj:5gj9
PDBsum5gj9
PubMed28604689
UniProtQ41931|ACCO2_ARATH 1-aminocyclopropane-1-carboxylate oxidase 2 (Gene Name=ACO2)

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