Structure of PDB 5gie Chain A

Receptor sequence
>5gieA (length=251) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSSVTL
DLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIE
VIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSHTLELIEPLIKFQVGLKK
LNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHP
PPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVF
G
3D structure
PDB5gie Regulation of the vitamin D receptor by vitamin D lactam derivatives.
ChainA
Resolution2.387 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 S252 Q255 I256 K260 P412 E416 I73 K77 S87 Q90 I91 K95 P244 E248
BS02 VDP A S233 R270 S271 S274 W282 C284 V296 S297 H393 Y397 S68 R105 S106 S109 W117 C119 V131 S132 H225 Y229 MOAD: Kd=769.2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5gie, PDBe:5gie, PDBj:5gie
PDBsum5gie
PubMed27500498
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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