Structure of PDB 5gic Chain A

Receptor sequence
>5gicA (length=237) Species: 10116 (Rattus norvegicus) [Search protein sequence]
LSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRPLSMLPHLADLVSYS
IQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWD
CGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAIC
IVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKL
ADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
3D structure
PDB5gic Regulation of the vitamin D receptor by vitamin D lactam derivatives.
ChainA
Resolution2.352 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 S252 I256 K260 P412 L413 E416 I55 S69 I73 K77 P229 L230 E233
BS02 DLC A S233 I267 R270 S271 S274 W282 V296 H393 Y397 S50 I84 R87 S88 S91 W99 V113 H210 Y214 MOAD: Kd=330.9nM
PDBbind-CN: -logKd/Ki=6.48,Kd=330.9nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5gic, PDBe:5gic, PDBj:5gic
PDBsum5gic
PubMed27500498
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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