Structure of PDB 5gcn Chain A

Receptor sequence
>5gcnA (length=166) Species: 5911 (Tetrahymena thermophila) [Search protein sequence]
MKGLLDFDILTNDGTHRNMKLLIDLKNIFSRQLPKMPKEYIVKLVFDRHH
ESMVILKNKQKVIGGICFRQYKPQRFAEVAFLAVTANEQVRGYGTRLMNK
FKDHMQKQNIEYLLTYADNFAIGYFKKQGFTKEHRMPQEKWKGYIKDYDG
GTLMECYIHPYVDYGN
3D structure
PDB5gcn Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A
ChainA
ResolutionN/A
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y71 F76 E78 V79 A80 L82 L114 I145 Y148
Catalytic site (residue number reindexed from 1) Y71 F76 E78 V79 A80 L82 L114 I145 Y148
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A Q32 L33 L82 A83 V84 N87 Q89 V90 F120 A121 Y124 F125 Q32 L33 L82 A83 V84 N87 Q89 V90 F120 A121 Y124 F125
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:5gcn, PDBe:5gcn, PDBj:5gcn
PDBsum5gcn
PubMed10403255
UniProtQ27198

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