Structure of PDB 5g5s Chain A

Receptor sequence
>5g5sA (length=692) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
FTMVLNKVTYKINAYKIKEEFIPKEVHFYRIKSFVNEAFNFYRFVNFYGG
MIINKKDKSFVLPYKVDNIPIDIEYIKSLKLEYVKPEIAEKLVRGYLKSV
HKIEPELSRIIKENIKVESYCEYEVKKHDGDYYLILNFRHTASITKHLWD
FVNRDKALLEEYVGKKIIFKPNPKVRYTISLVDAPNPQKIEEIMSHIIKY
YKWSEDMVKSTFGEIDYNQPIMYCEEILEPFAPQFCNLVFYMDELDSYIL
KELQSYWRLSNENKGKIINEIAKKLRFIDNTPKELEFMKFNNTPLLVKDV
NKNPTKIYSTNTLFTWIYNQNAKIYLPYDVPEIIRNKNLLTYILIDEEIK
DELKAIKDKVNKMFRNYNKIANKTELPKFNYANRWKYFSTDDIRGIIKEI
KSEFNDEICFALIIGKEKYKDNDYYEILKKQLFDLKIISQNILWENWRKD
DKGYMTNNLLIQIMGKLGIKYFILDSKTPYDYIMGLDTGLNHRVGGCTVV
YDSEGKIRRIQPIETPAPGERLHLPYVIEYLENKANIDMENKNILFLRDG
FIQNSERNDLKEISKELNSNIEVISIRKNNKYKVFTSDYRIGSVFGNDGI
FLPHKTPFGSNPVKLSTWLRFNCGNEEGLKINESIMQLLYDLTKMNYSAL
YGEGRYLRIPAPIHYADKFVKALGKNWKIDEELLKHGFLYFI
3D structure
PDB5g5s Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.
ChainA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A A289 L292 I295 N297 A272 L275 I278 N280
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0044355 clearance of foreign intracellular DNA
GO:0051607 defense response to virus

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5g5s, PDBe:5g5s, PDBj:5g5s
PDBsum5g5s
PubMed28319084
UniProtQ58717|AGO_METJA Protein argonaute (Gene Name=ago)

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