Structure of PDB 5g4a Chain A

Receptor sequence
>5g4aA (length=261) Species: 28901 (Salmonella enterica) [Search protein sequence]
TLSIPPSIQCQTEAACRLITRVTGDTLRAIHLYGSAVAGGLKPNSDIDLL
VTICQPLTEAQRATLMQELLALSSPPGASAEKRALEVTVVLYSQLVPWCF
PPSREMQFGEWLREDICQGIYEPAQQDWDMVLLITQILETSIPLKGERAE
RLFTPAPAAQLLKALRYPLDLWQSTADVQGDEYHIVLTLARIWYTLSTGR
FTSKDAAADWLLPQLPEDYAATLRAAQREYLGLEQQDWHILLPAVVRFVD
FAKAHIPTQFT
3D structure
PDB5g4a Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase fromSalmonella enterica.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.47: streptomycin 3''-adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D47 D49 D46 D48
BS02 MG A D47 D49 E87 D46 D48 E86
BS03 ATP A S36 S46 D47 D49 D130 L133 Q137 R192 I193 T196 F202 K205 Y231 S35 S45 D46 D48 D129 L132 Q136 R191 I192 T195 F201 K204 Y230
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0009012 aminoglycoside 3''-adenylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0070566 adenylyltransferase activity
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:5g4a, PDBe:5g4a, PDBj:5g4a
PDBsum5g4a
PubMed29871922
UniProtQ8ZPX9|S3AD_SALTY Aminoglycoside (3'') (9) adenylyltransferase (Gene Name=aadA)

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