Structure of PDB 5g2t Chain A

Receptor sequence
>5g2tA (length=467) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482) [Search protein sequence]
RQQEKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVG
CPLSQPSRAALWSGMMPHQTNVRSNSSEPVNTRLPENVPTLGSLFSESGY
EAVHFGKTHDMGSLRGFKHKEPVAKPFTDPEFPVNNDSFLDVGTCEDAVA
YLSNPPKEPFICIADFQNPHNICGFIGENAGVHTDRPISGPLPELPDNFD
VEDWSNIPTPVQYICCSHRRMTQAAHWNEENYRHYIAAFQHYTKMVSKQV
DSVLKALYSTPAGRNTIVVIMADHGDGMASHRMVTKHISFYDEMTNVPFI
FAGPGIKQQKKPVDHLLTQPTLDLLPTLCDLAGIAVPAEKAGISLAPTLR
GEKQKKSHPYVVSEWHSEYEYVTTPGRMVRGPRYKYTHYLEGNGEELYDM
KKDPGERKNLAKDPKYSKILAEHRALLDDYITRSKDDYRSLKVDADPRCR
NHTPGYPSHEGPGAREI
3D structure
PDB5g2t How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 H33 S72 R76 K125 H127 N153 H188 D291 H292 K304
Catalytic site (residue number reindexed from 1) D14 H15 S54 R58 K107 H109 N135 H170 D273 H274 K286
Enzyme Commision number 3.1.6.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UAP A S72 N93 H188 C191 R238 K304 E386 Y387 S54 N75 H170 C173 R220 K286 E368 Y369
BS02 ZN A C233 C234 H470 H477 C215 C216 H452 H459
Gene Ontology
Molecular Function
GO:0004065 arylsulfatase activity
GO:0015024 glucuronate-2-sulfatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5g2t, PDBe:5g2t, PDBj:5g2t
PDBsum5g2t
PubMed28630303
UniProtQ8A7C8|HEXSF_BACTN Delta 4,5-hexuronate-2-O-sulfatase (Gene Name=BT_1596)

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