Structure of PDB 5fzi Chain A

Receptor sequence
>5fziA (length=461) Species: 9606 (Homo sapiens) [Search protein sequence]
SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPP
FACDVDKLHFTPRIQRLNELEAQTRVKLGGGGARDYTLRTFGEMADAFKS
DYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVR
DGIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMC
FSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELF
VSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQ
GFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADV
LDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQC
VKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLY
PMMNALKLRAE
3D structure
PDB5fzi Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Mc3095
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G481 Y488 H499 E501 H587 A599
Catalytic site (residue number reindexed from 1) G189 Y196 H207 E209 H295 A307
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C692 C695 C715 H718 C400 C403 C423 H426
BS02 MN A H499 E501 H587 H207 E209 H295
BS03 FIG A R98 Y488 F496 H499 K517 R75 Y196 F204 H207 K225
External links
PDB RCSB:5fzi, PDBe:5fzi, PDBj:5fzi
PDBsum5fzi
PubMed
UniProtQ9UGL1|KDM5B_HUMAN Lysine-specific demethylase 5B (Gene Name=KDM5B)

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