Structure of PDB 5fy9 Chain A

Receptor sequence
>5fy9A (length=460) Species: 9606 (Homo sapiens) [Search protein sequence]
SMFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPP
FACDVDKLHFTPRIQRLNELEAQTRVKLGGGGARDYTLRTFGEMADAFKS
DYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVR
DIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCF
SSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFV
SQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQG
FNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVL
DVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCV
KCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYP
MMNALKLRAE
3D structure
PDB5fy9 Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Pyruvate
ChainA
Resolution2.03 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G481 Y488 H499 E501 H587 A599
Catalytic site (residue number reindexed from 1) G188 Y195 H206 E208 H294 A306
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A N91 L413 T416 E419 N68 L122 T125 E128
BS02 MN A H499 E501 H587 H206 E208 H294
BS03 ZN A C692 C695 C715 H718 C399 C402 C422 H425
BS04 ZN A C706 C708 C723 C725 C413 C415 C430 C432
BS05 PYR A Y488 F496 K517 Y195 F203 K224
External links
PDB RCSB:5fy9, PDBe:5fy9, PDBj:5fy9
PDBsum5fy9
PubMed
UniProtQ9UGL1|KDM5B_HUMAN Lysine-specific demethylase 5B (Gene Name=KDM5B)

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