Structure of PDB 5fxx Chain A

Receptor sequence
>5fxxA (length=444) Species: 9606 (Homo sapiens) [Search protein sequence]
KDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLG
LFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTI
AKYAQYQASSFQESLREENEKRKGPFKTIKFGTNIDLSDNKKWKLQLHEL
TKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFC
SVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEA
NVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAV
ERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQY
QTLREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKT
YIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLS
3D structure
PDB5fxx Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with Oxaloacetate
ChainA
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H1093 E1095 H1173 H193 E195 H273
BS02 OAA A Y1082 K1084 T1090 H1093 N1103 V1175 N1183 Y182 K184 T190 H193 N203 V275 N283
BS03 ZN A C1278 C1281 C1305 C1308 C378 C381 C405 C408
External links
PDB RCSB:5fxx, PDBe:5fxx, PDBj:5fxx
PDBsum5fxx
PubMed
UniProtO14607|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

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