Structure of PDB 5fxw Chain A

Receptor sequence
>5fxwA (length=444) Species: 9606 (Homo sapiens) [Search protein sequence]
KDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLG
LFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTI
AKYAQYQASSFQESLREENEKRKGPFKTIKFGTNIDLSDNKKWKLQLHEL
TKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFC
SVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEA
NVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAV
ERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQY
QTLREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKT
YIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLS
3D structure
PDB5fxw Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with Fumarate
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1278 C1281 C1305 C1308 C378 C381 C405 C408
BS02 MN A H1093 E1095 H1173 H193 E195 H273
BS03 FUM A K1084 T1090 H1093 N1103 H1173 N1183 K184 T190 H193 N203 H273 N283
External links
PDB RCSB:5fxw, PDBe:5fxw, PDBj:5fxw
PDBsum5fxw
PubMed
UniProtO14607|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

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