Structure of PDB 5fxv Chain A

Receptor sequence
>5fxvA (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]
KDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLG
LFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTI
AKYAQYQASSFQESLREENEKGPFKTIKFGTNIDLSDNKKWKLQLHELTK
LPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSV
NINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANV
PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVER
YEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQT
LREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYI
VHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLS
3D structure
PDB5fxv Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with N05859B
ChainA
Resolution1.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1278 C1281 C1305 C1308 C376 C379 C403 C406
BS02 MN A H1093 E1095 H1173 H191 E193 H271
BS03 MN1 A K1084 T1090 H1093 N1103 W1113 K182 T188 H191 N201 W211
External links
PDB RCSB:5fxv, PDBe:5fxv, PDBj:5fxv
PDBsum5fxv
PubMed
UniProtO14607|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

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