Structure of PDB 5fx5 Chain A

Receptor sequence
>5fx5A (length=180) Species: 12130 (rhinovirus A2) [Search protein sequence]
GPEEEFGMSLIKHNSCVITTENGKFTGLGVYDRFVVVPTHADPGKEIQVD
GITTKVIDSYDLYNKNGIKLEITVLKLDRNEKFRDIRRYIPNNEDDYPNC
NLALLANQPEPTIINVGDVVSYGNILLSGNQTARMLKYSYPTKSGYCGGV
LYKIGQVLGIHVGGNGRDGFSAMLLRSYFT
3D structure
PDB5fx5 Design and Structure-Activity Relationships of Novel Inhibitors of Human Rhinovirus 3C Protease.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H40 E71 G145 C147
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HOV A F25 H40 E71 L127 S128 T142 K143 G145 C147 H161 V162 G163 G164 N165 F170 F25 H40 E71 L127 S128 T142 K143 G145 C147 H161 V162 G163 G164 N165 F170
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5fx5, PDBe:5fx5, PDBj:5fx5
PDBsum5fx5
PubMed27265257
UniProtP04936|POLG_HRV2 Genome polyprotein

[Back to BioLiP]