Structure of PDB 5fuv Chain A

Receptor sequence
>5fuvA (length=173) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
HGRIELIIGPMFAGKTTELMRRVQRHKHAQRSCYIIKYTGDTRHDQRALT
ANVSVSNLHDVGDEWRKYDVIAVDEGQFFPDVAAFCSKAADSGKVVIVSA
LDADYLQEPFEEICLLVSRADSVVKLSAVCMECHNRKASFTYRTVKSDER
KLVGGSDMYMSVCRSCYETKRNM
3D structure
PDB5fuv Cell Cycle Regulation and Novel Structural Features of Thymidine Kinase, an Essential Enzyme in Trypanosoma Brucei.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A S235 C236 T261 A262 S32 C33 T50 A51
BS02 THM A M214 E286 F289 L312 D315 Y316 T352 R361 K362 L363 V364 G365 Y370 M11 E75 F78 L101 D104 Y105 T141 R150 K151 L152 V153 G154 Y159
BS03 ZN A C341 C344 C374 C377 C130 C133 C163 C166
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5fuv, PDBe:5fuv, PDBj:5fuv
PDBsum5fuv
PubMed27426054
UniProtQ38CF2

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