Structure of PDB 5fut Chain A

Receptor sequence
>5futA (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
DEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSL
PDTTATLGDEPRKVLLRLYGGAEAMVLESVMFAILAERSLGPKLYGIFPQ
GRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGT
MEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVF
CHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMY
DYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIK
EEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQK
RKLGV
3D structure
PDB5fut Plasmodium Falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.32: choline kinase.
2.7.1.82: ethanolamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PQ7 A D306 Y333 Y354 W420 W423 I433 F435 Y440 D204 Y231 Y252 W318 W321 I331 F333 Y338 MOAD: Kd=352nM
PDBbind-CN: -logKd/Ki=6.45,Kd=352nM
External links
PDB RCSB:5fut, PDBe:5fut, PDBj:5fut
PDBsum5fut
PubMed27616047
UniProtP35790|CHKA_HUMAN Choline kinase alpha (Gene Name=CHKA)

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