Structure of PDB 5fsx Chain A

Receptor sequence
>5fsxA (length=233) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
EFVTYSGEESSPTRTRILSAALSPAERAIFDVPIEKWLSIDRSSLSGWKC
AVPRPVTIEQLRPVDPSDAILRHIALYRGPVTDLQLDAIVNAANTRCLGG
GGVDGAIHRVAGPLLLRECATFNGCQTGECRLTKGYQLPARYVLHTVGPV
GERPDMLRKCYRSILSLALKNGLRSIGFCCVSTGVYGYPLLPATRIALGE
TRKFLEEHGGALDMCCFACFQEDEYKTYEKCVG
3D structure
PDB5fsx Proximal Adp-Ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A A120 G130 V131 C208 S210 G212 V213 Y214 F248 E252 A92 G102 V103 C180 S182 G184 V185 Y186 F220 E224 MOAD: Ka=540M^-1
PDBbind-CN: -logKd/Ki=2.72,Kd=1.9mM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding

View graph for
Molecular Function
External links
PDB RCSB:5fsx, PDBe:5fsx, PDBj:5fsx
PDBsum5fsx
PubMed27064071
UniProtC9ZP98

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