Structure of PDB 5fs8 Chain A

Receptor sequence
>5fs8A (length=474) Species: 9606 (Homo sapiens) [Search protein sequence]
QDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPP
LSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGG
VAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAG
AEVKSRTTLFRKIGDFRSLEKISREVKSITIIGEGFLGSELACALGRKAR
ALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGV
SSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVN
AELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAK
PYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQS
GTGIRSESETESRASEITIPPDYGKGVIFYLRDKVVVGIVLWNIFNRMPI
ARKIIKDGEQHEDLNEVAKLFNIH
3D structure
PDB5fs8 Structure/Function Relations in Aifm1 Variants Associated with Neurodegenerative Disorders
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G138 G140 T141 A142 E164 D165 R172 P173 K177 K232 V233 T260 G261 R285 K286 N403 G437 D438 E453 H454 H455 A458 F482 W483 G14 G16 T17 A18 E40 D41 R48 P49 K53 K108 V109 T136 G137 R161 K162 N279 G313 D314 E329 H330 H331 A334 F358 W359
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:5fs8, PDBe:5fs8, PDBj:5fs8
PDBsum5fs8
PubMed27178839
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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