Structure of PDB 5fs7 Chain A

Receptor sequence
>5fs7A (length=449) Species: 9606 (Homo sapiens) [Search protein sequence]
DKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPL
SKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGV
AVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGSTPRSLSAIDRAGA
EVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARA
LGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVS
SGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNA
ELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKP
YWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATYGKG
VIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHE
3D structure
PDB5fs7 Structure/Function Relations in Aifm1 Variants Associated with Neurodegenerative Disorders.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G138 G139 G140 T141 A142 E164 D165 R172 P173 K177 K232 V233 T260 F284 N403 G437 D438 E453 H454 H455 A458 W483 G13 G14 G15 T16 A17 E39 D40 R47 P48 K52 K107 V108 T135 F159 N278 G312 D313 E328 H329 H330 A333 W358
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:5fs7, PDBe:5fs7, PDBj:5fs7
PDBsum5fs7
PubMed27178839
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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