Structure of PDB 5fr8 Chain A

Receptor sequence

>5fr8A (length=707) Species: 470 (Acinetobacter baumannii)

IFVTAEEQVKQSLGVSVITKEDLEKLPVRNDISDYVRRMPGVNLTGNSAT
GQRGNNRQIDIRGMGPENTLILVDGKPINSRNSVRYGWKGERDTRGDSNW
VPAEAIESIEVLRGPAAARYGSGAAGGVVNIITKKVTNETHGSVEFYTSQ
PEDSKEGSSNRVGFNVSGPLIKDVLSYRLYGNYNKTEADDVDINKSIGST
AAGREGVKNKDISGRLAWQATDQQTVLLDISSSKQGNIYSGDSQLNANAE
ADAILSQLIGKETNTMYRDSYALTHEGDWSWGKSKLVAQYDKTHNKRLPE
GLAGSVEGKINNLDDKATSRLETLRFNGEANIPFEYYLPQVLTVGTEWVE
DRFKDNVSTTQGKDSSGSGYGDQLAKGDRSKMESRIASAYIEDNLKVTDS
TDVVLGLRFDDHSKSGSNWSPSLNITQKLNDYFTLKGGVAKAYKAPNMYQ
NAEGYLLSTNGNGCPANIESRCLLQGNGDLKPETSVNKELGIQFQKDIVN
ASLTWFRNDYKDKIVAGTHVVGTVDGSSTNANTGAVTNTKWNILRWENTP
KALIQGFEGSLGLDFGDIRWTNNFTYMMDSKDKQTGNPLSLVPIYTINSI
FDYDITDQLDVNFVFTQYGRQKSRQFAENRLESGIGSGGANSALKPSTVK
SYSTAGINVGYKFSDQISTRVGVSNLFDKQILRDSNSISQTYNEPGRAYY
ASLKYSF

3D structure

• PDB: 5fr8 Structure and Function of the PiuA and PirA Siderophore-Drug Receptors from Pseudomonas aeruginosa and Acinetobacter baumannii.
• Chain: A
• Resolution: 2.83 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	C8E	A	L584 N595 F597	L561 N572 F574

Gene Ontology

Molecular Function

• GO:0015288 porin activity
• GO:0015343 siderophore-iron transmembrane transporter activity
• GO:0015344 siderophore uptake transmembrane transporter activity
• GO:0038023 signaling receptor activity

Biological Process

• GO:0006826 iron ion transport
• GO:0015891 siderophore transport
• GO:0033214 siderophore-dependent iron import into cell
• GO:0044718 siderophore transmembrane transport

Cellular Component

• GO:0009279 cell outer membrane
• GO:0046930 pore complex

External links

• PDB: RCSB:5fr8, PDBe:5fr8, PDBj:5fr8
• PDBsum: 5fr8
• PubMed: 28137795
• UniProt: D0C8V9|PIRA_ACIB2 Probable TonB-dependent siderophore receptor PirA (Gene Name=pirA)