Structure of PDB 5fqv Chain A

Receptor sequence
>5fqvA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVY
TFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPSYDLLLEMLD
3D structure
PDB5fqv Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VQI A T347 L349 A350 E353 F404 L525 V533 V534 T38 L40 A41 E44 F95 L213 V221 V222 MOAD: ic50=610nM
PDBbind-CN: -logKd/Ki=6.21,IC50=610nM
BindingDB: IC50=160nM
External links
PDB RCSB:5fqv, PDBe:5fqv, PDBj:5fqv
PDBsum5fqv
PubMed26819673
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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