Structure of PDB 5fqt Chain A

Receptor sequence

>5fqtA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]

ALSLTADQMVSALLDAEPPILYSEYDPTRPFSMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVY
TFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPSYDLLLEMLD

3D structure

PDB

5fqt Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.

Chain

Resolution

1.99 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	7QN	A	L346 T347 A350 E353 L387 M388 L391 H524 V533 V534	L37 T38 A41 E44 L78 M79 L82 H212 V221 V222	MOAD: ic50=160nM PDBbind-CN: -logKd/Ki=6.80,IC50=160nM BindingDB: IC50=170nM

External links

PDB	RCSB:5fqt, PDBe:5fqt, PDBj:5fqt
PDBsum	5fqt
PubMed	26819673
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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