Structure of PDB 5fqr Chain A

Receptor sequence
>5fqrA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVY
TFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMVPSYDLLLEMLD
3D structure
PDB5fqr Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
ChainA
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QHG A L346 T347 A350 E353 M421 L525 V534 L37 T38 A41 E44 M112 L213 V217 MOAD: ic50=26nM
PDBbind-CN: -logKd/Ki=7.59,IC50=26nM
BindingDB: IC50=25nM
External links
PDB RCSB:5fqr, PDBe:5fqr, PDBj:5fqr
PDBsum5fqr
PubMed26819673
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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