Structure of PDB 5fpv Chain A

Receptor sequence
>5fpvA (length=337) Species: 9606 (Homo sapiens) [Search protein sequence]
SARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYD
DIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPR
YSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLV
EGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKR
LERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFM
ITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMD
VFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLK
3D structure
PDB5fpv Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
ChainA
Resolution2.44 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G171 Y178 H189 E191 H277 S289
Catalytic site (residue number reindexed from 1) G152 Y159 H170 E172 H258 S270
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69: [histone H3]-trimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H189 E191 H277 H170 E172 H258
BS02 MMK A Y133 Y176 Y178 F186 H189 E191 K207 W209 H277 S289 T290 N291 Y122 Y157 Y159 F167 H170 E172 K188 W190 H258 S270 T271 N272
BS03 ZN A C235 H241 C307 C309 C216 H222 C288 C290
External links
PDB RCSB:5fpv, PDBe:5fpv, PDBj:5fpv
PDBsum5fpv
PubMed27214403
UniProtO75164|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)

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