Structure of PDB 5fpo Chain A

Receptor sequence
>5fpoA (length=305) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
DLSSRVNELHDLLNQYSYEYYVENPSVPDSEYDKLLHELIKIEEEHPEYK
TVDSPTVRVGGEAQASFNKVNHDTPMLSLGNAFNEDDLRKFDQRIREQIG
NVEYMCELKIDGLAVSLKYVDGYFVQGLTRGDGTTGEDITENLKTIHAIP
LKMKEPLNVEVRGEAYMPRRSFLRLNEEKEKNEQLFANPRNAAAGSLRQL
DSKLTAKRKLSVFIYSVNDFTDFNARSQSEALDELDKLGFTTNKNRARVN
NIDGVLEYIEKWTSQRESLPYDIDGIVIKVNDLDQQDEMGFTQKSPRWAI
AYKFP
3D structure
PDB5fpo Detection of Secondary Binding Sites in Proteins Using Fragment Screening.
ChainA
Resolution1.83 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E110 K112 D114 Y219 K307
Catalytic site (residue number reindexed from 1) E107 K109 D111 Y215 K303
Enzyme Commision number 6.5.1.2: DNA ligase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 10L A L82 E110 Y219 K283 L79 E107 Y215 K279
BS02 10L A S19 Y20 H150 P153 G243 S17 Y18 H147 P150 G239
BS03 10L A R172 F175 P193 D276 R169 F172 P189 D272
Gene Ontology
Molecular Function
GO:0003911 DNA ligase (NAD+) activity

View graph for
Molecular Function
External links
PDB RCSB:5fpo, PDBe:5fpo, PDBj:5fpo
PDBsum5fpo
PubMed26655740
UniProtQ9AIU7|DNLJ_STAAU DNA ligase (Gene Name=ligA)

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