Structure of PDB 5fph Chain A

Receptor sequence
>5fphA (length=395) Species: 10090 (Mus musculus) [Search protein sequence]
DLPSSFTGYFKKFNTGEEIISQEILNLIELRMRKGNIQLTNSAISDALKE
IDSSVLNVAVTGETGSGKSSFINTLRGIGNEEEGAAKTGVVEVTMERHPY
KHPNIPNVVFWDLPGIGSTNFPPNTYLEKMKFYEYDFFIIISATRFKKND
IDIAKAISMMKEEFYFVRTKVDSDITNEADGKPQTEKVLQDIRLNCVNTF
RENGIAEPPIFLLSNKNVCHYDFPVLMDELISDLPIYKRHNFMVSLPNIT
DSVIEKKRQFLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYR
TVFGVDETSLQRLARDWEIEVDQVEAMIKSPAVFKPTDETIQERLSRYIQ
EFCLANGYLLPKNSFLKEIFYLKYYFLDMVTEDAKTLLKEICLRN
3D structure
PDB5fph The Immunity-Related Gtpase Irga6 Dimerizes in a Parallel Head-to-Head Fashion.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A T78 G79 S80 G81 K82 S83 S84 T102 G103 V105 K184 D186 S231 N232 K233 T64 G65 S66 G67 K68 S69 S70 T88 G89 V91 K170 D172 S214 N215 K216
BS02 MG A S83 E106 D126 S69 E92 D112
BS03 MG A D150 E176 E177 D136 E162 E163
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
GO:0042802 identical protein binding
Biological Process
GO:0009617 response to bacterium
GO:0010506 regulation of autophagy
GO:0019221 cytokine-mediated signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0042832 defense response to protozoan
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0020005 symbiont-containing vacuole membrane
GO:0031965 nuclear membrane
GO:0032580 Golgi cisterna membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fph, PDBe:5fph, PDBj:5fph
PDBsum5fph
PubMed26934976
UniProtQ9QZ85|IIGP1_MOUSE Interferon-inducible GTPase 1 (Gene Name=Iigp1)

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