Structure of PDB 5fnu Chain A

Receptor sequence
>5fnuA (length=288) Species: 10090 (Mus musculus) [Search protein sequence]
RLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLY
AVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHI
YAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV
GGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGY
DGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGH
TFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
3D structure
PDB5fnu Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L6I A Y334 G364 R415 G462 F478 R483 S508 G509 Y525 S555 A556 Y572 S602 G603 Y9 G39 R90 G137 F153 R158 S183 G184 Y200 S230 A231 Y247 S277 G278 MOAD: Kd=0.0013uM
PDBbind-CN: -logKd/Ki=8.89,Kd=0.0013uM
External links
PDB RCSB:5fnu, PDBe:5fnu, PDBj:5fnu
PDBsum5fnu
PubMed27031670
UniProtQ9Z2X8|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Gene Name=Keap1)

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