Structure of PDB 5fnr Chain A

Receptor sequence
>5fnrA (length=289) Species: 10090 (Mus musculus) [Search protein sequence]
GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLL
YAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGH
IYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYA
VGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGG
YDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDG
HTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
3D structure
PDB5fnr Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
ChainA
Resolution1.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XMS A R415 G462 F478 R483 S508 G509 Y525 S555 A556 Y572 R91 G138 F154 R159 S184 G185 Y201 S231 A232 Y248 MOAD: Kd=59uM
PDBbind-CN: -logKd/Ki=4.23,Kd=59uM
External links
PDB RCSB:5fnr, PDBe:5fnr, PDBj:5fnr
PDBsum5fnr
PubMed27031670
UniProtQ9Z2X8|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Gene Name=Keap1)

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