Structure of PDB 5fmz Chain A

Receptor sequence

>5fmzA (length=712) Species: 1601067 (Influenza B virus (B/Memphis/13/2003))

SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYNLRPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLAD
LFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSNE
SSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQTIS
RLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLTW
EDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKEC
LEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQKT
NYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEMNL
LSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYV
LFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRG
DTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCRV
NGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDRV
NSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESR
RLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWLGF
EKEGSKVLESVD

3D structure

• PDB: 5fmz Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains.
• Chain: A
• Resolution: 3.4 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K330 W364 T366 G367 D368 G369 L370 T371 Y372 P394 H506 R508 V513 T515 R558 V559 N560 G561 Q566 N692	K321 W355 T357 G358 D359 G360 L361 T362 Y363 P385 H497 R499 V504 T506 R549 V550 N551 G552 Q557 N683

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:5fmz, PDBe:5fmz, PDBj:5fmz
• PDBsum: 5fmz
• PubMed: 26711008
• UniProt: Q5V8Z9