Structure of PDB 5fm0 Chain A

Receptor sequence
>5fm0A (length=247) Species: 1423 (Bacillus subtilis) [Search protein sequence]
TFYSVRMRASMNGSHGKHISGGERLIPFHEMKHTVNALLEKGLSHSRGKP
DFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEGVSRDV
IEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEK
WALHSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKK
MGYQRITAMKEYGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEE
3D structure
PDB5fm0 Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters.
ChainA
Resolution2.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.14: 6-carboxyhexanoate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WAQ A E31 G124 A125 R145 V146 R170 I171 L177 S194 D195 Y199 Y211 R213 R227 E23 G116 A117 R137 V138 R162 I163 L169 S186 D187 Y191 Y203 R205 R219
BS02 PPV A H26 S28 G29 K49 H53 R145 D196 H18 S20 G21 K41 H45 R137 D188
BS03 MG A D195 D196 D187 D188
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042410 6-carboxyhexanoate-CoA ligase activity
Biological Process
GO:0009102 biotin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5fm0, PDBe:5fm0, PDBj:5fm0
PDBsum5fm0
PubMed28414710
UniProtP53559|BIOW_BACSU 6-carboxyhexanoate--CoA ligase (Gene Name=bioW)

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