Structure of PDB 5fl1 Chain A

Receptor sequence
>5fl1A (length=703) Species: 818 (Bacteroides thetaiotaomicron) [Search protein sequence]
SLQPPPQQLIVNKTIDLPAVYQLNGGEEANPHAVKVLKELLSSKKGMLIS
IGEKGDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERGTYYALQTFA
QLLKDGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKFYGKNKM
NTYIYGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDFVWAIHP
GQDIKWNKEDRDLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQKQAELL
NYIDEKFAQVKPDINQLVMCPTEYNKSWSNPNGNYLTTLGDKLNPSIQIM
WTGDRVISDITRDGISWINERIKRPAYIWWNFPVSDYVRDHLLLGPVYGN
DTTIAKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDTWQTWKDAIR
TILPSAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLKAFKEGK
NYDKADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQFKLTAEM
GEEVLKMVEGRNESYFLRKYNHVKALQQQMFYIDQTSNQNPYQPGVKTAT
RVIKPLIDRTFATVVKFFNQKFNAHLDATTDYMPHKMISNVEQIKNLPLQ
VKANRVLISPANEVVKWAAGNSVEIELDAIYPGENIQINFGCTWGRLEIS
TDGKEWKTVDLKQKESRLSAGLQKAPVKFVRFTNVSDEEQQVYLRQFVLT
IEK
3D structure
PDB5fl1 Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by humanO-GlcNAcase.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DV1 A G135 K166 D242 C278 Y282 M308 T310 W337 N339 D344 G127 K158 D234 C270 Y274 M300 T302 W329 N331 D336 PDBbind-CN: -logKd/Ki=8.49,Ki=3.2nM
Gene Ontology
Molecular Function
GO:0015929 hexosaminidase activity
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding
GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006517 protein deglycosylation
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5fl1, PDBe:5fl1, PDBj:5fl1
PDBsum5fl1
PubMed29997861
UniProtQ89ZI2|OGA_BACTN O-GlcNAcase BT_4395 (Gene Name=BT_4395)

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