Structure of PDB 5fj8 Chain A

Receptor sequence
>5fj8A (length=1422) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAH
NPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYI
WRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGI
SINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIRGFCQRL
KGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEK
VTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQ
IGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTP
YNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDF
ITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGK
QVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGS
QILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGN
RGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCN
EEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVS
QMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLS
PPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTS
ANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPY
AIMETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHS
LREYINGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVS
QLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPMNVTLGV
PRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLSDVAFYV
QDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKIQASDVN
IIGKDRIAINVFPSENDVFYRMQQLRRALPDVVVKGLPDISRAVINIRDD
GKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIRE
INYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLAS
FEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISE
KDLVPKRCLFESLSNEAALKAN
3D structure
PDB5fj8 Molecular Structures of Unbound and Transcribing RNA Polymerase III.
ChainA
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K360 R378 Q477 A880 Y884 R1373 E1390 K1391 K353 R371 Q470 A873 Y877 R1335 E1352 K1353
BS02 dna A K165 F1374 K164 F1336
BS03 rna A Q275 D515 Q268 D508
BS04 ZN A C67 C77 H80 C66 C76 H79
BS05 ZN A N109 C110 N108 C109
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fj8, PDBe:5fj8, PDBj:5fj8
PDBsum5fj8
PubMed26605533
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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