Structure of PDB 5fhn Chain A

Receptor sequence
>5fhnA (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT
IVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSK
PFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAV
FDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRK
PCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKW
WYDKGECG
3D structure
PDB5fhn Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5XO A S14 Y16 Y61 P89 L90 T91 R96 L138 G141 S142 T143 E193 T195 M196 Y220 W255 S10 Y12 Y57 P85 L86 T87 R92 L134 G137 S138 T139 E189 T191 M192 Y216 W251 PDBbind-CN: -logKd/Ki=5.90,Ki=1.27uM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5fhn, PDBe:5fhn, PDBj:5fhn
PDBsum5fhn
PubMed26862980
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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