Structure of PDB 5fgz Chain A

Receptor sequence
>5fgzA (length=697) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LAIVFAVLIAIYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPDMTISK
NEMVKLLEATQYRQVSKMTRPGEFTVQANSIEMIRRPFDFPDSKEGQVRA
RLTFDGDHLATIVNMENNRQFGFFRLDPRLITMISSPNGEQRLFVPRSGF
PDLLVDTLLATEDTLTQQLVKNLFLSSERSYWRKANEAYMALIMDARYSK
DRILELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGM
VKGASIYNPWRNPKLALERRNLVLRLLQQQQIIDQELYDMLSARPLGVQP
RGGVISPQPAFMQLVRQELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKA
AVEGIPALKKQRKLSDLETAIVVVDRFSGEVRAMVGGSEPQFAGYNRAMQ
ARRSIGSLAKPATYLTALSQPKIYRLNTWIADAPIALRQPNGQVWSPQND
DRRYSESGRVMLVDALTRSMNVPTVNLGMALGLPAVTETWIKLGVPKDQL
HPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGKVLYQ
SFPQAERAVPAQAAYLTLWTMQQVVQRGTGRQLGAKYPNLHLAGKTGTTN
NNVDTWFAGIDGSTVTITWVGRDNNQPTKLYGASGAMSIYQRYLANQTPT
PLNLVPPEDIADMGVDYDGNFVCSGGMRILPVWTSDPQSLCQQSEMQ
3D structure
PDB5fgz Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-beta-Lactamases and Penicillin-Binding Proteins.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.99.28: peptidoglycan glycosyltransferase.
3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M0E A Q271 K274 N275 E281 Y315 E323 V354 K355 G356 S358 I359 Q168 K171 N172 E178 Y212 E220 V251 K252 G253 S255 I256
BS02 5VW A S510 S572 L611 T682 T699 G700 T701 T702 N703 S407 S469 L508 T579 T596 G597 T598 T599 N600
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008658 penicillin binding
GO:0008955 peptidoglycan glycosyltransferase activity
Biological Process
GO:0009252 peptidoglycan biosynthetic process
GO:0046677 response to antibiotic
Cellular Component
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fgz, PDBe:5fgz, PDBj:5fgz
PDBsum5fgz
PubMed26731698
UniProtP02919|PBPB_ECOLI Penicillin-binding protein 1B (Gene Name=mrcB)

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