Structure of PDB 5fgk Chain A

Receptor sequence
>5fgkA (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYA
LKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYA
EHDLWHIIKFHRAVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANI
LVMGEGPERGRVKIADMGFAVTFWYRAPELLLGARHYTKAIDIWAIGCIF
AELLTSEPIFHCRQPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMK
DFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQ
DPYFLEDPLPTSDVFAGCQIPYPKREFLTEE
3D structure
PDB5fgk Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
ChainA
Resolution2.36 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 T196
Catalytic site (residue number reindexed from 1) D144 K146 N149 D166 T172
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5XG A V27 Y32 A50 K52 I79 F97 A100 L158 D173 R356 V27 Y32 A50 K52 I79 F97 A100 L151 D166 R325 MOAD: ic50=1.7nM
PDBbind-CN: -logKd/Ki=8.77,IC50=1.7nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5fgk, PDBe:5fgk, PDBj:5fgk
PDBsum5fgk
PubMed26796641
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

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