Structure of PDB 5ff7 Chain A

Receptor sequence
>5ff7A (length=325) Species: 301447 (Streptococcus pyogenes serotype M1) [Search protein sequence]
ITLTENKRKSMEKLSVDGVISALAFDQRGALKRMMAQHQTKEPTVEQIEE
LKSLVSEELTPFASSILLDPEYGLPASRVRSEEAGLLLAYEKTGYDATTT
SRLPDCLDVWSAKRIKEAGAEAVKFLLYYDIDGDQDVNEQKKAYIERIGS
ECRAEDIPFYLEILTYDEKIADNASPEFAKVKAHKVNEAMKVFSKERFGV
DVLKVEVPVNMKFVEGFADGEVLFTKEEAAQAFRDQEASTDLPYIYLSAG
VSAKLFQDTLVFAAESGAKFNGVLCGRATWAGSVKVYIEEGPQAAREWLR
TEGFKNIDELNKVLDKTASPWTEKM
3D structure
PDB5ff7 NON-STEREOSPECIFIC SUBSTRATE CLEAVAGE BY TAGATOSE-BISPHOSPHATE CLASS I ALDOLASE
ChainA
Resolution2.092 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.2.40: tagatose-bisphosphate aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G3P A A25 D27 Q28 K125 E163 K205 S249 A250 L275 G277 R278 A24 D26 Q27 K124 E162 K204 S248 A249 L274 G276 R277
BS02 G3H A Q28 R29 G30 A31 R34 T94 G95 Q27 R28 G29 A30 R33 T93 G94
BS03 CA A E238 T241 E237 T240
BS04 CA A E83 E84 E82 E83
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0009024 tagatose-6-phosphate kinase activity
GO:0009025 tagatose-bisphosphate aldolase activity
GO:0016829 lyase activity
GO:0061595 6-deoxy-6-sulfofructose-1-phosphate aldolase activity
Biological Process
GO:0005988 lactose metabolic process
GO:0019512 lactose catabolic process via tagatose-6-phosphate
GO:1902777 6-sulfoquinovose(1-) catabolic process
GO:2001059 D-tagatose 6-phosphate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5ff7, PDBe:5ff7, PDBj:5ff7
PDBsum5ff7
PubMed
UniProtP63705|LACD2_STRP1 Tagatose 1,6-diphosphate aldolase 2 (Gene Name=lacD2)

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