Structure of PDB 5fet Chain A

Receptor sequence
>5fetA (length=802) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
RCNEKKAIFGEDTLMEDHLQLREKLSEDIEMIKASLKNNLVCSTLNDNEI
LTLSNYMQFFVFKGGDLVIKQGEKGSYFFIINSGKFDVYVNDKKVKSMGK
GSSFGEAALIHNTQRSATIMAETDGTLWGVQRSTFRATLKQLSNRNFNEN
RSFIDSVSVFDMLTEAQKNMITNACVIQMFKPGETIVKQGDYGDVLFILK
EGKATVFINDKEIRVLNKGSYFGERALLYDEPRSATIIAKEPTACASICR
KLLNIVLGNLQVVLFRNIMTEALQQSEIFRQFSAEQLNDLADTAIVRDYP
ANYHILHKDKVKSVKYLIVLEGKVELFLDDESIGILTRGKSFGDQYVLNQ
KQKFRHTVKSLDVCKIALITESCLADCLGDNNIDASIDHNNKKSIIKKMY
IFRYLSEQQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEVTK
NGKRLRTLGKNDYFGERALLYDEPRTASIISKATSVECWFVDKSVFLQII
QGPMLTHLEERIKMQDTKVEMHELETERIIGRGGTVKLVHHKPTQIRYAL
KCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVRTFKDCFYFLTELV
TGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENIL
LDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILGKGYGCTVDIWA
LGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLMK
RLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGET
YA
3D structure
PDB5fet Crystal Structure of PVX_084705 in presence of Compound 2
ChainA
Resolution3.07 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D657 K659 N662 D675 T692
Catalytic site (residue number reindexed from 1) D643 K645 N648 D661 T678
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1TR A I540 V548 A561 T611 V614 E618 L664 I674 I530 V536 A549 T597 V600 E604 L650 I660
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
GO:0030553 cGMP binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fet, PDBe:5fet, PDBj:5fet
PDBsum5fet
PubMed
UniProtA5K0N4|KGP_PLAVS cGMP-dependent protein kinase (Gene Name=PKG)

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