Structure of PDB 5fdo Chain A

Receptor sequence
>5fdoA (length=142) Species: 9606 (Homo sapiens) [Search protein sequence]
GDELYRQSLEIISRYLREQATGAKGATSRKALETLRRVGDGVQRNHETAF
QGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHL
KTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
3D structure
PDB5fdo Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5X2 A F228 M231 M250 G262 R263 T266 L267 F270 G271 F50 M53 M72 G84 R85 T88 L89 F92 G93 PDBbind-CN: -logKd/Ki=6.44,Ki=361nM
BindingDB: Ki=361nM,IC50=400nM
BS02 5X2 A N223 H224 N45 H46 PDBbind-CN: -logKd/Ki=6.44,Ki=361nM
BindingDB: Ki=361nM,IC50=400nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5fdo, PDBe:5fdo, PDBj:5fdo
PDBsum5fdo
PubMed26878343
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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