Structure of PDB 5fc4 Chain A

Receptor sequence
>5fc4A (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
GDELYRQSLEIISRYLREQATAGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIANEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKT
INQESCIAPLAESITDVLVRTKRDWLVAQRGWDGFVEFFH
3D structure
PDB5fc4 Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5WL A A227 F228 M231 V249 M250 V253 G262 R263 T266 L267 F270 A47 F48 M51 V69 M70 V73 G82 R83 T86 L87 F90 MOAD: Ki=231nM
BindingDB: IC50=200nM,Ki=231nM
BS02 5WL A L235 R248 V249 H252 V253 D256 L55 R68 V69 H72 V73 D76 MOAD: Ki=231nM
BindingDB: IC50=200nM,Ki=231nM
BS03 5WK A G262 F319 G82 F139
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5fc4, PDBe:5fc4, PDBj:5fc4
PDBsum5fc4
PubMed26878343
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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