Structure of PDB 5fby Chain A

Receptor sequence
>5fbyA (length=490) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
LAASAPRRSSLGFTLDLHRIQRDYIDLVPKHWHVISLSLSDGGHDLCITR
LQAGQAPFVLRLPLERAVFDFHTGRAELLEIIKEINRTCHDSRDMAAKGE
REKWWAEREALDQRLKELLMNIEHVWLGGFRGVFSQHGRRPELLEKFRAM
FEGVLDKHLPSRKVVLDGNVLELFIGLGDATKSGADFDEELTDLLYFVVD
ILQFHGERNAYDEIDFDSMVVETMDALMAYHAEANAAPSHAHTILVLDKQ
LHVFPWESLPCLQGLAVSRIPSLACLRKLLLDRRRSSSDPRSAGHHAPLS
GGTYILNPSSDLLSTQKTFESLFSTHLHSPNSWTRIISRPPTEPEFLSAL
THSPILLYFGHGSGAQYIRSRNIRHLDHCRATVLLMGCSSAALTAKGEFE
PSGPVWNYMLAGAPAVVGTLWDVTDRDIDRFAGGVLEGWGVLPEGCMGGR
NGLSLVQAVAKARDRCRFRYVTAAAAVVYGIPVYVDVDGK
3D structure
PDB5fby Structural basis of cohesin cleavage by separase.
ChainA
Resolution1.898 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.49: separase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F1695 D1698 I1702 S1718 L1959 D1960 L1985 W2128 F13 D16 I20 S36 L247 D248 L273 W406
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fby, PDBe:5fby, PDBj:5fby
PDBsum5fby
PubMed27027290
UniProtG0SHM3

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