Structure of PDB 5fbr Chain A

Receptor sequence
>5fbrA (length=465) Species: 9606 (Homo sapiens) [Search protein sequence]
SWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLP
QLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSRGTKLR
KLILSRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPA
RVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVP
ARIPENVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELL
AFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKK
QSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN
GNILLDAEGHIIHIDFGFILSSSFKLTTEFVDVMGGLDGDMFNYYKMLML
QGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQ
LQLLVEQMVDGSMRS
3D structure
PDB5fbr PI4KB in complex with Rab11 and the MI359 Inhibitor
ChainA
Resolution3.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.67: 1-phosphatidylinositol 4-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5W7 A P381 I562 K564 Y598 I610 P612 V613 V614 L678 I688 D689 P181 I238 K240 Y274 I286 P288 V289 V290 L354 I364 D365 BindingDB: IC50=27nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5fbr, PDBe:5fbr, PDBj:5fbr
PDBsum5fbr
PubMed
UniProtQ9UBF8|PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (Gene Name=PI4KB)

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